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These inflammatory mediators might stimulate nociceptors, leading to generation and further chronification of painful symptoms

type 2 diabetes, obesity or overweight, etc.)

The taxonomical features (i.e., phyla and genera) were analyzed via carrying out a linear mixed model [46] on all the features in the data set, whilst taking into account the false discovery rate (type I error) under repeated testing through Benjamini & Hochberg correction [49], of the P-values calculated via type III ANOVA using the Satterthwaites method [47]

This led to large dedicated weight-loss trials in people with overweight or obesity, including people without diabetes

Thyroid function should be checked at baseline and monitored during treatment