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Neurology, 41 (11), 17261732

Our analysis of data from a large number of clinical trials shows that GLP-1RAs are not only safe from a psychiatric perspective but may improve mental health outcomes

These pathways include modulation of neuroinflammation, glucose metabolism, and reward system activity, offering a framework for understanding how GLP-1RAs might exert their effects on mood, cognition, and behavior

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If you have pain, numbness, or tingling in the buttock, thigh, calf, or foot especially on one side that suggests nerve involvement and deserves evaluation beyond routine back pain treatment