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The amount of fat in the liver is the key modifiable risk factor at every stage

Semaglutide has demonstrated benefits for individuals with existing cardiovascular issues by lowering significant adverse cardiovascular events by 20%

51 One significant challenge is the high rate of gastrointestinal adverse events associated with these compounds, which may be related to their pharmacokinetic properties and direct gastrointestinal irritation

A Phase 2 trial published in The New England Journal of Medicine (Jastreboff et al., 2023) reported a mean body weight reduction of approximately 24% at the highest dose over 48 weeks in participants without type 2 diabetes results that attracted considerable scientific interest