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The SELECT trial, completed in 2023 with over 17,600 participants, showed a 20% reduction in cardiovascular events in patients with established cardiovascular disease and overweight or obesity without diabetes

In some cases, doses are adjusted after 4 to 6 weeks based on lab results (especially IGF-1 levels, a marker of GH activity) and how the patient is feeling

SHP is involved in bile acids synthesis by downregulating the gene transcription of cholesterol 7 alpha-hydroxylase (CYP7A1), a rate-limiting enzyme in bile acid synthesis

It also renders an even skin tone with a soft, smooth and shiny texture, fair and pink complexion and improved overall physical health

Understanding these risk factors can help patients and healthcare providers anticipate and manage digestive symptoms more effectively