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After statistics, we found that the expression level of these proteins increased after adding berberine, but after giving GLP-1R inhibitor, this trend of berberine was inhibited (Figures 7DF)

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Based on prior reports linking mitochondrial protein stability to a short fragment within the cyclic structural domain of SLC25A39 (amino acids 7286) that mediates glutathione (GSH) response and recruits SLC25A39 to AFG3L2 for proteolysis, we generated a deletion mutant lacking this fragment (aa72-86), confirmed by Sanger sequencing (Fig

Relative MACE risk estimates for semaglutide vs comparators There was a reduced relative risk of MACE with semaglutide vs comparators across the baseline CV risk continuum (Fig

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