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Higher doses showed even greater reductions

For severely obese people, the National Institutes of Health (NIH) recognizes bariatric surgery as the only effective treatment for maintaining long-term weight loss for individuals who had no success with diet, exercise and other common weight-loss strategies

That activation step was resolved in detail when researchers reported the first near-atomic cryo-electron microscopy structure of the activated, full-length GLP-1 receptor bound to its Gs protein

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