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Melanin production is an ongoing biological process, and skin tone will gradually return towards baseline if treatment is discontinued and sun protection is neglected

A phase 2 study of once-weekly LY3437943 compared with placebo in participants who have obesity or are overweight with weight-related comorbidities [Internet]

The changes in plasma volume induce an elevation in plasma renin activity, and aldosterone secretion is increased, contributing to the potassium loss associated with thiazide diuretic therapy

However, human studies are limited

If bloodwork shows low D levels, your provider may recommend higher doses or prescription-strength supplements