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Sibutramine (Meridia) Withdrawn from the Canadian market in 2010 after the SCOUT trial linked it to an increased risk of heart attack and stroke in higher-risk patients

The insulin resistance in T2DM and NAFLD determines an increase in hepatic production and reduced muscle glucose uptake, as well as lowering lipolysis in adipose tissue and increasing hepatic lipogenesis, consequently raising glucose and circulating free fatty acids (FFAs) levels [5]

Hypoglycemia Risk: While metformin alone rarely causes hypoglycemia, risk increases when combined with other anti-diabetic agents (e.g., insulin, sulfonylureas)

Bergman BC, Tsvetkova T, Lowes B, Wolfel EE

It helps protect our mitochondria and cells, detoxifies environmental toxins, and balances our immune system