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In mice, knockout of ChREBP has been shown to reduce hepatic fatty acid synthesis by 65% compared to wild-type controls, but also to promote insulin resistance, delayed glucose clearance, and severe intolerance to simple carbohydrates, such as sucrose and fructose (resulting in death in the majority of animals) due to an inability to shunt fructose into glycolytic pathways [48]
This is what happens in injury or during hypoxic events, such as a heart attack.[ref] Back to mitochondrial dysfunction and depression The link between mitochondrial dysfunction and depression has been shown in a lot of studies
The following pathways were shown to be affected: regulation of protein biosynthesis, response to stress, inflammation, carcinogenesis, and the Wnt pathway (Kipp et al., 2009)
Sertraline suppresses testis and adrenal steroid production and steroidogenic gene expression while increasing lh in plasma of male rats resulting in compensatory hypogonadism