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4 Despite the multitude of existing treatments for HSincluding topicals, oral antibiotics, and biologicsmany patients are dissatisfied with available therapies 5 , underscoring the need for innovative treatments

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Mice lacking the gene for ghrelin or its receptor have normal food intake when fed chow, probably due to compensatory adaptation during embryonic development, but show a degree of protection from obesity when fed a high-fat diet, especially from an early age (Sun et al., 2003, 2004

Initial combination therapy with canagliflozin plus metformin versus each component as monotherapy for drug-nave type 2 diabetes