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Oral dosing ranges discussed in research community use Phase Weeks 12 (start low) Daily dose 50 mg once daily Notes Morning dosing is the pattern most often reported

Intranasal formulations of cyanocobalamin are not suitable for vitamin B12 absorption test (Schilling Test)

Phase 3: Maintenance (Weeks 912) Dose: 23 weekly Pulsed administration keeps the repair signal present without turning the protocol into constant stimulation

This is the run-in period where NNMT inhibition is being established

[21] Within cells, cyanocobalamin is converted to methylcobalamin and 5- deoxyadenosylcobalamin, coenzymes that participate respectively in homocysteine remethylation to methionine and in the isomerization of methylmalonyl-CoA to succinyl CoA, reactions essential for DNA synthesis, erythropoiesis, and myelin maintenance