However, an elevated IFN- is not necessarily virus-induced, as it has also been reported in Borrelia -induced long Lyme/PTLDS (80, 81)
336,337 Expression of antioxidants either fails to be induced or is decreased, allowing increased expression of reactive oxygen species to affect tubulointerstitial fibrosis through necrosis, apoptosis, activation of interstitial fibroblasts and pericytes, proliferation of endothelial cells, and epithelial-mesenchyme transition (figure 1)
Effects of oxidative stress on viral infections: an overview
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