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The molecular mechanisms of the neuroprotective effects of GLP-1R agonists include signaling pathways such as ERK signaling, PI3K signaling, RhoA activity, MAPK/NF-B signaling, and the Epac/Akt pathway

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2 It is estimated that 1 billion people worldwide are affected by the disease, with an alarming steep increase in the prevalence of obesity since the 1970s among all age groups