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Saris, [email protected] This article was submitted to Nutrition and Metabolism, a section of the journal Frontiers in Nutrition Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Although standard therapeutic modalities, including surgery, radiotherapy, chemotherapy, targeted therapy and immunotherapy, have improved, their clinical efficacy is often compromised by drug resistance, tumor microenvironment remodeling and immune evasion (2)

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