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When the gut lining is inflamed and permeable, neurotransmitter production is disrupted, inflammatory cytokines cross into systemic circulation and reach the brain, and the vagus nerve the primary communication cable between gut and brain transmits distress signals that manifest as anxiety, brain fog, and fatigue

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Arnold focused on feeling his middle deltoids work during every rep

Another study reported BD patients (75 euthymic, 14 manic/hypomanic, 45 depressive) had higher levels of all cytokines, including slL-2R, C-reactive protein (CRP) and sTNFR1 than the healthy controls [73], with depressed BD patients having reduced sTNFRl and slL-2R compared to those in mania and euthymia [73]