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Rybelsus may be appropriate for patients who: Prefer oral medication Are hesitant about injections Travel frequently Want a lower-barrier introduction to GLP-1 therapy Unlike injectable semaglutide, Rybelsus must be taken on an empty stomach with specific administration instructions for proper absorption

It is a requirement backed by clinical trial data showing that slower titration reduces gastrointestinal side effects by 40 to 60% compared to starting at full dose

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We assessed the risk of suicide or suicide attempts following initiation of GLP-1 RA, DPP-4 inhibitors or SGLT-2 inhibitors, respectively

The treatment is regarded as relatively safe, but like any medicine, has potential side effects: Diarrhoea Dizziness Headache Hot flush Nausea Skin reactions Urine discolouration If you are allergic to cobalt please notify your clinician (1-3% of the population have this allergy)