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It plays a major role in detoxification, immune defense, cellular repair, and protecting cells from oxidative stress

Cruciferous vegetables are dual-acting: They provide some dietary glutathione directly AND activate Nrf2-mediated upregulation of glutathione synthesis genes via sulforaphane [27][28]

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The Zr released from Mn-MOF downregulated GSH efficiently (Figure 5G), thus elevating Mn-MOF-induced ROS concentration, leading to the deactivation of GPX4 and ROS-enhanced ferroptosis