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Animal studies have shown that T4 administration significantly improves functional recovery after traumatic brain injury, even when treatment is delayed by 24 hours post-injury

Yoshimura H, Nariai Y, Terashima M, Mitani T, Tanigawa Y

The liver metabolises fat through beta-oxidation and exports triglycerides as VLDL particles, processes regulated by insulin sensitivity, glucagon, and adipose tissue lipolysis

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Phase I trials are concerned with the safety of a new medication or treatment and hence why it is tested in healthy participants