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The extended half-life results from reduced renal clearance, as the unbound peptide avoids the protective complexes that normally prevent glomerular filtration
A large meta-analysis of 64 trials with over 25,500 adults with type 2 diabetes showed that GLP-1s were more effective at reducing A1C levels compared to placebo and traditional diabetes drugs
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We conclude that mitophagy affects ischemic heart disease by promoting cardiomyocyte hypertrophy and fibrosis, the progression of oxidative stress, the development of inflammation, and cardiomyocyte death, and that the specific mechanisms of mitophagy are worthy of further investigation
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