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However, it is not yet clear what the role of IL-1 is in human gouty inflammation, since off-label IL-1 inhibition alone with the monoclonal antibody canakinumab is remarkably effective in humans with acute gouty arthritis ( Management of Acute Gouty Arthritis )

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In these cases, a change in lipid peroxidation was found to occur simultaneously with an inverse change in the activity of antioxidant enzymes ( Reference Liang, Liu and Xu 23 , Reference Wang, Li and Lu 32 , Reference Hirano, Hamajima and Horiuchi 34 )