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Interestingly, the generation of R-2-HG from glutamine has been proven to occur rapidly in patient-derived chondrosarcoma cell lines harboring endogenous IDH mutations, indicating fundamental metabolic differences between cells that harbor IDH1/2 mutations and those that do not 121

The combination of sugars optimises the skin's water reserves and facilitates the hydric flow through the skin's layers by increasing the synthesis of aquaporins (water channels)

The activation energy of 300600 kJmol 1 can only be rationalized in terms of chemical kinetics corresponding to the decomposition of molecular compounds with dehydration, deamination, or decarboxylation processes within the crystal lattice [59, 60]

The MTHFR enzyme is responsible for converting folate into its active form, 5-methyltetrahydrofolate

doi: 10.3389/fphys.2021.625287 186 OzonoffAJayaveluNDLiuSMelamedEMillirenCEQiJet al