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Semaglutide: More Than Just a Weight-Loss Drug Semaglutide has transformed the management of Type 2 Diabetes Mellitus and Obesity by targeting one of the bodys natural metabolic pathwaysthe GLP-1 receptor

While the medication has demonstrated significant efficacy in glycaemic control, it can produce various side effects as the body adjusts

Use was lower among older patients (over 75), those with advanced-stage disease (stage IV), patients with HR-/HER2- tumors, Latinx and Asian patients, individuals with limited English proficiency, and those receiving care at community medical centers rather than academic institutions

In December 2025, Nektar Therapeutics reported topline data from its Phase 2b REZOLVE-AA trial evaluating rezpegaldesleukin in patients with severe-to-very-severe AA

The pharmaceutical company that produces semaglutide has advised that supply will still be limited throughout 2024 due to a global shortage