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The hypothalamic-pituitary-thyroid axis The figure illustrates the hypothalamic-pituitary-thyroid axis in two side-by-side panels, with arrows indicating hormone pathways and the word iodine labeled near the thyroid gland: Left panel (sufficient dietary iodine): The hypothalamus releases thyrotropin-releasing hormone (TRH), which stimulates the anterior pituitary to secrete thyroid-stimulating hormone (TSH)