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In the vasculature, GLP-1RAs and DPP-4 inhibitors mitigate LPS-induced endothelial permeability, inflammation, and microvascular thrombosis by activating AMPK and CaMKK, reducing adhesion molecule expression (VCAM-1, ICAM-1), and improving outcomes in septic shock

Brand-name options cost $1,000-1,400 monthly

Shelf life considerations also matter, especially for multi-use vials that are opened and used over several weeks

Replace every 24 hours for consistent support