When compared to pre-surgery, GLP-1R antagonist administration more significantly increased activation in the caudate nucleus to visual food cues and in the insula to gustatory food cues after RYGB, indicating an effect of surgery on the actions of GLP-1R blockage (Jennifer et al., Discussion To our knowledge, this study is the most up to date and comprehensive translational review of the effect of GLP-1 on reward
Tirzepatide tends to be the better fit when: the goal is more significant weight loss (15 percent or more of body weight), the patient has type 2 diabetes with A1C above target on prior therapies, prior single-pathway GLP-1 use produced limited results, or the patient tolerated GLP-1s reasonably well and wants a stronger next step
17- Corradini E, Schmidt PJ, Meynard D, et al
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