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Tirzepatide (Mounjaro, Zepbound) is a dual GIP and GLP-1 receptor agonist used for type 2 diabetes and weight management

doi: 10.1038/s41392-024-01772-w 13 DaiMOuyangWYuYWangTWangYCenMet al

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(2022) 11:e63998

The effectiveness of once-daily subcutaneous liraglutide administration for weight loss management in adults was established in five large-scale randomized multicentre phase 3 trials [49,50,51,52,53], four of which were part of the SCALE program (Satiety and Clinical AdiposityLiraglutide Evidence in nondiabetic and diabetic individuals), leading to its approval at a dose of 3.0 mg subcutaneous once-daily (weekly increased from 0.6 mg to 3 mg/day)