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The lower panel shows the SHAP summary plot for the impact of baseline variables in predicting the change in BMI in response to semaglutide

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7,11 GLP-1 agonists help modulate chronic inflammation associated with obesity by suppressing proinflammatory cytokines such as TNF-, IL-6, and IL-1, improving endothelial function

PMID 40465419 characterised hexarelin as the primary hepatic metabolite of alexamorelin a structurally related compound from which hexarelin is generated by carboxypeptidase-mediated C-terminal alanine cleavage (alexamorelin signal decreased approximately 150-fold within 3 hours of hepatocyte incubation)

( f ) Food intake, ( g ) RER (effect of treatment F(1,10) = 6.34 p = 0.031), ( h ) energy expenditure (with ANCOVA using BW as covariate), ( i ) ambulatory activity and ( j ) body weight change of WT mice treated with VEH or acyl-GIP ( d - j , n = 6 per group