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Factors predisposing to thrombus formation include decreased velocity of blood flow, hypercoagulability, and endothelial cell damage

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Additionally, SLE patients and murine models have been found to spontaneously produce autoantibodies against these SRs, impairing the apoptotic cell removal ability of these two SRs (323, 327)

However, they must be used cautiously, as their legal status and long-term effects vary depending on the peptide and jurisdiction