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Last reviewed: June 30, 2026 Last updated: June 30, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

Interestingly, recent studies have shown that some AD risk genes that mainly exist in the microglia of mice exhibit greater expression in human BECs, suggesting a partial evolutionary transfer of AD risk genes and pathways from microglia to the vasculature from mice to humans and a possible interaction between microglia and endothelial cells (Yang et al., 2022)