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Nausea, vomiting, constipation, and diarrhea increase in frequency and intensity at higher doses, especially during dose transitions

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It is often associated with impaired functionality ( Several lines of evidence point to the presence of low-grade inflammation and oxidative stress in patients with bipolar disorder (Rosenblat and McIntyre, 2016), while findings to some extent are inconsistent and have been limited by methodological issues (Wang et al., 2009)

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