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Keywords: acne, dermatology, glp-1 receptor agonists, hidradenitis suppurativa, metabolic improvement, sebaceous gland activity, semaglutide Introduction Glucagon-like peptide-1 receptor agonists (GLP-1 RAs), particularly semaglutide, have reshaped the therapeutic landscape for type 2 diabetes mellitus and obesity because of their potent effects on glycemic control, weight reduction, and cardiometabolic risk modulation [1,2]

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Retatrutide, targeting all three metabolic receptors, consistently outperforms semaglutide in head-to-head comparisons within trial populations