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However, GR113808 did not affect the expression of genes involved in triglyceride synthesis (Mogat1, diacylglycerol O-acyltransferase 1 (Dgat1), and Dgat2), fatty acid synthesis (SCD-1), and fatty acid uptake (PPAR- and CD36) or peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1) (Fig

Its neurotrophic properties particularly BDNF upregulation have opened parallel lines of investigation in neurodegeneration and cognitive aging research

Clin Pharmacokinet 9(5):375403 Siddoway LA, Roden DM, Woosley RL (1985) Clinical pharmacology of old and new antiarrhythmic drugs

Its challenge is that combining two satiety/gastric-emptying pathways may still create tolerability limits

Acta Pharm Sin B 2023