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Alternatively, unexpected (given recent literature in AS-3 49 ), methionine accumulation was observed in supernatants across all groups except E-Sol5 at +4 C (Supplemental Fig

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Management: Rotate sites, use smaller insulin syringes, and keep injection volume low (0.5 mL) Potential for IGF-1 Resistance or Downregulation Using IGF1 LR3 continuously without breaks can desensitize IGF1 receptors , reducing effectiveness over time