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discovered that nucleobase derivatives can serve as new MALDI matrices for the ISD of oligonucleotides

While melanocortin agonists have historically failed to meet these criteria, limiting their use to genetic obesity, emerging melanocortins show promise as both monotherapies and GLP-1 adjuvants for general obesity patients

The prepared samples were observed under a scanning electron microscope (FEI Quanta250, FEI Company, USA)

We intentionally avoid bulking agents so the solids correspond predominantly to the target peptide, which simplifies mass-based calculations during method development

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