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For the CagriSema combination, gastrointestinal adverse events affected 79.6% of participants compared to 39.9% with placebo

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However, even when combined with chemotherapy, personalized vaccination did not result in significant survival differences, as demonstrated in the treatment of CRPC with personalized autologous dendritic-cell-based cancer vaccine (DCvac) plus docetaxel [171]

A comprehensive understanding of pharmacological mechanisms is therefore essential for developing personalized treatment regimens