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Introduction The incidence of non-communicable diseases such as diabetes, obesity, and hypertension has been growing in the last five decades, reaching high prevalence in developing countries, with serious consequences to the future of human beings ( via gluconeogenesis, and improving tissue insulin sensitivity, mostly white fat and muscle tissue ( Due to the effectiveness of metformin treatment, the drug has been prescribed after metabolic disease diagnosis

Notably, the immune system influences bone metabolism primarily through the innate and adaptive response