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Methylglyoxal-induced glycation changes adipose tissue vascular architecture, flow and expansion, leading to insulin resistance

Roughly 25-40% of total weight lost on GLP-1-class drugs is lean mass , and retatrutide's fat-to-lean ratio in trials is comparable to semaglutide and tirzepatide most of what you lose is fat

Anyone with an elevated A1C level is encouraged to consult their health care provider

Disclosures/Conflicts of interest The authors whose names are listed immediately below certify that they have no affiliations with or involvement in any organization or entity with any financial interest or non-financial interest) in the subject matter or materials discussed in this article

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