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At week 36, significant within-group reductions in AST, ALT, and GGT levels were observed across all treatment groups (all p 0.05)

Fatigue emerged as the second most frequently reported complaint despite limited representation in RCT datasets which may reflect differences between structured trial environments and real-world use

Additional studies are needed to further elucidate the exact mechanism of action as well as the frequency that PPIs can lead to dementia

It should be noted that the cerebral cortex and the cerebellum interestingly lack the expression of the GLP-1R in rat models [51]