GLP-1 plays an important role in glucose homeostasis and is secreted into the hepatic portal system in response to elevated glucose levels from food intake 10 , stimulating insulin synthesis and release from the pancreas 11
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In the alpha cells of the islets, GLP-1 receptor activation suppresses glucagon secretion, a process mediated by somatostatin release from adjacent delta cells.54,57 Beyond the pancreas, GLP-1 receptors are widely expressed in extrapancreatic tissues, including the heart, vascular smooth muscle, lungs, liver, gastrointestinal tract, vagus nerve, and enteric nervous system.58 GLP-1 receptor agonists exhibit varying degrees of homology with endogenous GLP-1 but possess extended durations of action
Using 30mg vials for the maintenance phase: One 10mg vial for weeks 1-4
Data limitations: We have very limited data on transfer to breast milk
