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ASA guidance states that claims like decrease appetite, burn fat, and speed up metabolism are likely to be medicinal claims that should not be made for unauthorised products

As the image below shows, fat consumption has steadily risen over the last century since we discovered how to extract oil from crops at scale, fuelled by synthetic fertilisers

This is the shared mechanism across the entire class and the primary reason all three compounds reduce caloric intake

Prescriptions are based on patient eligibility, and patient-specific compounding needs

Characterization of the cellular and metabolic effects of a novel enzyme-resistant antagonist of glucose-dependent insulinotropic polypeptide