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Calculating total product requirements A standard 16-week escalation protocol starting at 0.25mg and progressing through 0.5mg, 1.0mg, and 1.7mg weekly requires approximately 24mg of total semaglutide

Similarly to mice housed at RT, this shows that satiety initially increases but rapidly decreases with semaglutide treatment in mice at TN ( Supplemental Figure 1C-D )

Symptoms that persist beyond the initial 812 weeks of therapy, worsen over time, or significantly impair nutritional intake warrant further evaluation

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