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Preferably at least 90 % of copper peptide is released over 24hrs

People with type 2 diabetes face approximately 1.3 to 2 times increased risk of venous thromboembolism due to metabolic abnormalities including hyperglycaemia, insulin resistance, chronic inflammation, and endothelial dysfunction

This system achieves deep tumoral penetration, sustained drug release, and high local retention with favorable safety, offering a translatable strategy for localized PROTAC therapy in solid tumors like breast cancer