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Substantial evidence indicates that AST can downregulate microglial activation and reduce the production of cytotoxic factors

conducted a systematic review that found elevated cortisol levels in adolescents and young adults with depression, suggesting that HPA axis hyperactivity serves as a marker for stress and a precursor to depressive disorders [77]

Users stopping retinoids frequently report rapid regression of benefits within 4-8 weeks including increased breakouts sometimes exceeding pre-treatment levels (retinoid rebound), accelerated fine line reappearance approaching or surpassing baseline, skin texture deterioration returning to pre-treatment roughness, and psychological dependency from dramatic visible decline creating pressure for continuous use despite side effect burden

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