The trial found that participants with obesity alone who got MariTide lost up to 20% of their body weight, on average, after 52 weeks, compared with just 2.6% in the placebo group
The study authors, including Eqram Rahman and Jean DA Carruthers, built a computer simulation model using the AesthetiSIM platform, to generate 25,000 virtual patients
In the treatment arm, the weight loss trajectory over 72 weeks was comparable in both groups: 18.3% weight reduction in MC4R mutation carriers versus 19.9% in noncarriers
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Seek emergency care (call 999 or go to A&E) if you experience: Chest pain, stroke symptoms (face drooping, arm weakness, speech difficulties) Severe breathlessness Confusion or severe acute headache with very high blood pressure Fainting episodes Arrange same-day clinical review if: Your blood pressure reading is 180/120 mmHg, even without symptoms You have symptoms of hypotension : persistent dizziness, lightheadedness (especially upon standing), blurred vision, or unusual fatigue You have postural symptoms : feeling faint or dizzy when moving from sitting to standing Contact your GP or diabetes specialist nurse for routine concerns such as: Home blood pressure readings consistently at or above 135/85 mmHg (or clinic readings 140/90 mmHg) Home readings consistently below 90/60 mmHg Blood pressure readings that show significant variation from your usual pattern New or worsening symptoms that might be blood pressure-related, even if readings appear normal Persistent gastrointestinal symptoms (nausea, vomiting, diarrhoea) that may lead to dehydration Questions about adjusting antihypertensive medications as weight loss progresses Regular scheduled reviews with your healthcare team are essential for monitoring blood pressure trends and making appropriate medication adjustments
Choosing a Protein Powder for GLP-1 Friendly Breakfasts When you're taking Ozempic or another GLP-1 medication, your appetite is reduced, and meals are smaller
