She states that in one of her published Phase 2 clinical trials, 100% of subjects receiving retatrutide experienced significant weight loss at doses of 8 mg/week and 12 mg/week
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Buse JB, Rosenstock J, Sesti G, et al
Adverse consequences of motility effects of GLP-1RAs In one study, the incidence of retained gastric contents in individuals using a GLP-1RA was 56%, compared with 19% for those not using GLP-1RAs (34), although notably there were more individuals with T2D and obesity in the group treated with GLP-1RAs
Novo Nordisk has also cited indirect comparison data suggesting that fewer patients discontinued oral semaglutide due to side effects compared with orforglipron, though the companies and independent commentators note the significant methodological limitations of such comparisons in the absence of a head-to-head obesity trial
