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Continued exploration of novel approaches to enhance skin permeability has focused on investigating combinations of penetration enhancers and their effects on macromolecule absorption and stratum corneum barrier lipids

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Daily high doses of B12 may not likely cause harm in most people, but extremely high doses should possibly be avoided unless a healthcare professional prescribes it

Although immune dysfunction is clear in ME/CFS, further studies using defined cohorts, standardised assays, and new technologies are required to determine specific patterns (30)