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4.2 Anti-inflammatory effects in rheumatoid arthritis RA is a chronic inflammatory disease that causes persistent inflammation of the synovial membrane and joint damage, potentially resulting in disability (175)

In chronic stress models, chronic variable psychological stress [28], restraint stress [29], and caffeine consumption [30, 31] were applied in the eligible studies (Fig

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However, lipoxygenase primarily contributes to cysteine starvation-induced ferroptosis rather than GPX4 deficiency-induced ferroptosis