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NAD also serves as a substrate for several enzyme families that trigger critical cellular processes

Western blot analysis was performed as described previously 9

However, unlike glycolytic and lipogenic pathways, where specific metabolic enzymes such as hexokinase 2 and FAS are known to be deregulated by oncogene(s) or by inactivation of tumor suppressors 16,17 , there is limited evidence for cancer-associated abnormal expression or activity of the enzymes directly involved in the FAO pathway

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Regarding the inflammatory response, it has been shown that intracellular GSH depletion represents the first event in the signaling process