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Research has shown that LCN2 overexpression can mitigate LPS-induced oxidative stress and ferroptosis by inhibiting PTGS2 expression in hepatocytes, thereby exerting a protective effect on the liver (Jiang et al., 2024)

10.1016/j.dscb.2021.100019 81 Van Den BroekM.BeghiE.GroupR

When levels are high, the liver can process toxins efficiently

Gremer L, Gilsbach B, Reza Ahmadian M, Wittinghofer A (2008) Fluoride complexes of oncogenic Ras mutants to study the Ras-RasGAP interaction

In the trial, palovarotene reduced the annualized heterotrophic ossification by 54% compared with standard of care without introducing new safety signals