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Shoemaker's research demonstrated that patients with CIRS consistently show severe abnormalities in inflammatory blood markers, including highly elevated TGF-beta1, C4a, and MMP-9, alongside drastically depleted levels of Melanocyte Stimulating Hormone (MSH) and Vasoactive Intestinal Polypeptide (VIP)

While existing literature provides experimental evidence for these mechanisms, it often generalizes specific findings as universally applicable which leads to an incomplete or even biased understanding for the antioxidant action of NAC

Braz J Pharm Sci 58 Finan B, Yang B, Ottaway N, Smiley DL, Ma T et al (2015) A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents

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